NADH for Fibromyalgia Pain Relief

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NADH, a coenzyme that increases brain activity, will be examined for the first time in the United States for its potential benefits to persons suffering from Chronic Fatigue Syndrome (CFS), a complex medical condition that affects approximately 601o of the U.S. population each year.

The Food and Drug Administration recently approved NADH for clinical trials, which began at Georgetown University Medical Center in June 1996 under the direction of Harry Preuss, M.D., Division of Nephrology, and Joseph A. Bellanti, M.D., Director of Georgetown’s International Immunology Center.

It would help with post-exertional malaise

A few studies have looked at supplementation with NADH plus coenzyme Q10 in people with ME/CFS. One published in 2015 suggested a significant reduction in fatigue versus placebo. The other, published in 2016, appeared to show reduced maximum heart rate during exercise. That could mean that it would help with post-exertional malaise, which is a defining symptom of the disease.

A 2011 review of available literature named NADH and magnesium as the only two supplements that had been shown to improve ME/CFS in studies. Earlier research suggested improvement in anxiety and maximum heart rate after a stress test.

Enada NADH (nicotinamide adenine dinucleotide)

Enada NADH (nicotinamide adenine dinucleotide) is the original and only patented, stabilized, and absorbable form of food grade NADH, formulated to provide sustained energy as well as a boost in mental alertness and clarity. Enada is used by thousands of people to help alleviate symptoms of chronic health conditions.

To quote Dr. Birkmayer “NADH is the biological Rocket Fuel. It is the biological form of hydrogen which reacts with the oxygen present in our cells to produce energy. The more NADH we have, the more energy we can produce.”

Cellular energy production

Enada is an enteric coated 5mg tablet of NADH and is the bio-available, anti-oxidant form of Vitamin B-3. It is essential to the production of ATP (cellular energy). ATP, or adenosine triphosphate, is the primary energy carrier of the body.


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NADH plays a key role in cellular energy production, particularly in the brain and central nervous system. NADH is also involved in basic metabolism, the breakdown of glucose and fats, and supplies energy to the brain, nerves, muscles, heart, and all other organs.


NADH supplements are widely available and don’t require a prescription. A safe, effective dosage for FMS and ME/CFS has not yet been established. Generally, the recommended dosage is typically 5 mg to 10 mg a day. It should be taken 30 minutes before a meal on an empty stomach. In Parkinson’s disease studies, the most effective dose was identified as 25 mg to 50 mg per day.

NADH can reduce fatigue

Georgetown’s initial trial of NADH will focus on its potential efficacy in patients with fibromyalgia. According to Dr. Bellanti, the primary symptom of fibromyalgia is a general, unexplainable lack of energy and widespread pain. Individuals suffering from fibromyalgia report that they are barely functioning, feel burned out, exhausted, and tired all the time. They may feel dragged out, depressed, experience deep weariness. In most instances, such fatigue cannot be relieved with adequate rest, adds Dr. Bellanti.

However, it is important to note that because prolonged fatigue can be the harbinger of a definable medical or psychological problem, anyone who experiences unexplained fatigue longer than one month should see his/her physician. If no medical or psychological problems can then account for the fatigue, and it has lasted for more than six months and impairs normal daily activities, then chronic fatigue syndrome could be considered the culprit.

NADH provides sustainable energy.

Enada helps symptoms of health conditions such as Chronic Fatigue Syndrome (CFS), Fibromyalgia, depression, Alzheimers, Parkinsons, Jet Lag, ADHD (Attention Deficit Hyperactivity Disorder), and provides sustainable energy. It also supports DNA repair, boosts immune system, and helps cell regeneration.

What was commonly used to help relieve symptoms of conditions resulting in lack of energy is now used by athletes, executives, and everyday people to increase energy, improve mental clarity, and improve physical performance. NADH also is a vital part in making the popular supplement CoQ10 effective into an antioxidant.

Depression and obesity

Georgetown researchers also hope to use the coenzyme in the treatment of depression and obesity, as well as with people who have a family history of Alzheimer’s disease in hopes of preventing mental deterioration, memory lapses, and concentration difficulties.

NADH is a safe

NADH is a safe, natural compound that has shown much promise in patients with Alzheimer’s and Parkinson’s disease in Europe, says Preuss. But much more extensive research is needed. This trial in Chronic Fatigue Syndrome patients is a first significant step down a tong road to investigate the many potential benefits of this energy producing coenzymes.

Side Effects of NADH

Side effects of NADH are rare, especially at low levels. Higher doses are associated with:

  • >Feeling overstimulated
  • >Insomnia
  • >Anxiety

While NADH supplementation appears quite safe, you should still watch for negative side effects.

Synthesis of the neurotransmitter dopamine

NADH has been known to improve symptoms of Fibromyalgia, among a number of other conditions. Since one of the main symptoms of FMS is lack of energy, NADH will help increase the energy production in the body naturally. NADH also supports the synthesis of the neurotransmitter dopamine.

These brain chemicals affect mood, memory, alertness and concentration. So by increasing the level of NADH in your cells, there is an increase in dopamine production and thus users feel elevated mental clarity, levels of concentration and memory capacity.

If you think you might benefit from NADH supplements, be sure to talk to your doctor about it. It’s also a good idea to bring it up with your pharmacist, who’s an expert on how different treatments may interact in your body.


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Featured Image : via Steady Health

  • NADH for Fibromyalgia & Chronic Fatigue Syndrome by Adriene Dellwo via Verywell Health
  • Alegre J, Roses JM, Javierre C, et al. Nictinamide Adenine Dinucleotide (NADH) in Patients With Chronic Fatigue Syndrome. Revista Clinica Espanola. 2010 Jun;210(6):284-8. doi: 10.1016/j.rce.2009.09.015. Article in Spanish; Abstract Referenced.
  • Alraek T, Lee MS, Choi TY, et al. Complementary and Alternative Medicine for Patients With Chronic Fatigue Syndrome: A Systematic Review. BMC Complementary and Alternative Medicine. 2011 Oct 7;11:87. doi: 10.1186/1472-6882-11-87.
  • Castro-Marrero J, Cordero MD, Segundo MJ, et al. Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome? 2015 Mar 10;22(8):679-85. doi: 10.1089/ars.2014.6181.
  • Castro-Marrero J, Saez-Francas N, Segundo MJ, et al. Effect of Coenzyme Q10 Plus Nicotinamide Adenine Dinucleotide Supplementation on Maximu Heart Rate After Exercise Testing in Chronic Fatigue Syndrome – A Randomized, Controlled, Double-Blind Trial.Clinical Nutrition (Edinburgh, Scotland). 2016 Aug;35(4):826-34. doi: 10.1016/j.clnu.2015.07.010.
  • Nicolson GL. Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements. Alternative Therapies in Health and Medicine. 2014 Winter;20 Suppl 1:18-25.

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